Experience
My research interests include epidemiology and vaccine development for freshwater fish. I have a lot of research experience in fish virus detection, virus phylogenetic analysis, and vaccine development for carp and salmonids viruses.
Projects
- Fish virus surveillance program.
- Epidemiological database for fish virus.
- Application of fish disease detection technology in northern China.
- Development of inactivated vaccine against infectious hematopoietic necrosis virus.
- Development of DNA vaccine against infectious hematopoietic necrosis virus.
- Mechanism of early protection in rainbow trout vaccinated with a DNA vaccine against infectious hematopoietic necrosis virus.
- Epidemiological investigation for infectious hematopoietic necrosis virus.
- Importation of immunological prevention and treatment strategies for infectious hematopoietic necrosis virus.
- Key technologies for industrialisation of a DNA vaccine against infectious hematopoietic necrosis virus.
- Safety assessment of a DNA vaccine against infectious hematopoietic necrosis virus.
- Infectious pancreatic necrosis virus inhibits infectious hematopoietic necrosis virus via clathrin mediated endocytosis in co-infection.
- Receptor function in viral interference between infectious pancreatic necrosis virus and infectious hematopoietic necrosis virus.
- Mechanism of viral interference between infectious pancreatic necrosis virus and infectious hematopoietic necrosis virus.
- Mechanism of autophagy induced by infectious hematopoietic necrosis virus in vitro.
- Reverse genetic manipulation on infectious hematopoietic necrosis virus.
- Development of oral yeast vaccine against infectious hematopoietic necrosis virus.
- Development and application of cytokines being used as adjuvant.
Publications
- Xu L., Zhao J., MiaoLiu, et al. 2019. Phylogeography and evolution of infectious hematopoietic necrosis virus in China. Molecular Phylogenetics and Evolution, 131, pp. 19-28
- Chen X., Zhou Y., Xu L.*. 2019. Isolation and Genetic Analysis of a Novel Nidovirus from Crucian Carp (Carassius auratus). Archieves of Virology, 164, pp. 1651–1654.
- Xu L., Zhao J., Miao L., et al. 2017. Bivalent DNA vaccine induces significant immune responses against infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus in rainbow trout. Scientific Reports, 7(1), pp. 5700
- Xu L.M., Zhao J.Z., Liu M., et al. 2017. A effective DNA vaccine against diverse genotype J infectious hematopoietic necrosis virus strains prevalent in China. Vaccine, 35(18), pp. 2420-2426.
- Xu L.M., Zhao J.Z., Liu M., et al. 2016. High throughput screening of recombinant antibodies against infectious hematopoietic necrosis virus from a combinatorial antibody library. Aquaculture, 460, pp. 32-36.
- Xu L.M., Zhao J.Z., Liu M., et al. 2016. Recombinant scFv antibodies against infectious pancreatic necrosis virus isolated by flow cytometry. Journal of Virological Methods, 237, pp. 204-209.
- Ji F., Zhao J.Z., Liu M., Xu L.M. 2017. Complete genomic sequence of an infectious pancreatic necrosis virus isolated from rainbow trout (Oncorhynchus mykiss) in China. Virus Genes, 1-11.
- Xu L., Zhang Y., Wang Q., et al. 2015. Bi-specific antibodies with high antigen-binding affinity identified by flow cytometry. International Immunopharmacology, 24(2), pp. 463-473.
- Xu L.M., Liu M., Zhao J.Z., et al. 2014. Epitope mapping of the infectious hematopoietic necrosis virus glycoprotein by flow cytometry. Biotechnology Letters, 36(10), pp. 2109-2116.
- Xu L.M., Li T.H., Zhou B., et al. 2014. scFv antibodies against infectious bursal disease virus isolated from a combinatorial antibody library by flow cytometry. Biotechnology Letters, 36(5), pp. 1029-35.
- Guo M., Xu L M., Zhou B., et al. 2014. Anchored periplasmic expression (APEx)-based bacterial display for rapid and high-throughput screening of B cell epitopes. Biotechnology Letters, 36(3), pp. 609-616.
- Li T., Xu L., Ren G., et al. 2013. A neutralization scFv antibody against IL-1β isolated from a NIPA-based bacterial display library. Current Pharmaceutical Biotechnology, 14(6), pp. 571-81.
- Guangming Ren, Liming Xu, Tongyan Lu, et al. 2019. Protective effects of lentinan on lipopolysaccharide induced inflammatory response in intestine of juvenile taimen (Hucho taimen, Pallas). International Journal of Biological Macromolecules, 121, pp. 317-325.
- Guangming Ren, Liming Xu, Tongyan Lu, et al. 2018. Structural characterization and antiviral activity of lentinan from Lentinus edodes mycelia against infectious hematopoietic necrosis virus. International Journal of Biological Macromolecules, 115, pp. 1202-1210.
- Zhao J.Z., Xu L.M., Liu M., et al. 2017. Preliminary study of an oral vaccine against infectious hematopoietic necrosis virus using improved yeast surface display technology. Molecular Immunology, 85, pp. 196.