The research and development mandate of NACA is addressed through five thematic work programmes and three cross-cutting work programmes that support sustainable aquaculture and aquatic resource management in the region.

Government membership of NACA is via accession to the NACA Agreement, an international treaty. The agreement also provides for associate membership by intergovernmental organisations and donor agencies. Current member governments of NACA are Australia, Bangladesh, Cambodia, China, Hong Kong SAR, India, Indonesia, I.R. Iran, Korea (DPR), Lao PDR, Malaysia, Maldives, Myanmar, Nepal, Pakistan, Philippines, Sri Lanka, Thailand and Vietnam.

NACA implements collaborative development assistance projects on issues of regional interest. Individual projects draw heavily on the personnel and facilities of participating centres in member states. Projects are essentially implemented by participating centres with the Secretariat acting as a coordinating body. NACA supports technical exchange, capacity building, institutional strengthening and policies for sustainable aquaculture development. Network partners include research centres, member governments, farmer associations, development agencies and the Food and Agriculture Organization of the United Nations.