In the absence of identified biotic or abiotic cause(s) of the syndrome, this disease card provides information on signs that can be used for presumptive (pond level) and confirmative (animal level) diagnosis of acute hepatopancreatic necrosis syndrome of shrimp. The syndrome involves mass mortalities of up to 100% during the first 20-30 days after stocking. Affected shrimp consistently show an abnormal hepatopancreas, which may be shrunken, swollen or discoloured; loose shells, corkscrew swimming, pale colouration and slow growth.