Tilapia lake virus (TiLV) is a relatively recent pathogen causing serious mortalities in farmed tilapia. The virus appears to be spreading via the usual pathway of importation of live fish with inadequate regard for biosecurity protocols. Countries that are at risk should establish surveillance for TiLV. Unusual tilapia mortalities should be investigated. Importation of live tilapia should probably be reconsidered until adequate biosecurity arrangements are in place. Links to some recent advisories and publications are provided.