Epizootic ulcerative syndrome (EUS) is a seasonal epizootic condition of wild and farmed, fresh and brackishwater fish. Of complex infectious aetiology, it is characterised by the presence of invasive Aphanomyces infection and necrotising ulcerative lesions typically producing a granulomatous response. The disease is now endemic in South-east and south Asia, and has recently extended to West Asia. EUS is indistinguishable from red spot disease of eastern Australia and mycotic granulomatosis of Japan.