Some varieties of freshwater fish have low growth potential but remain economically attractive due to market preferences. The endangered catfish Horabagrus brachysoma is one such fish, which has limited production but high market demand, and a number of favourable biological characteristics. This article provides guidelines for the culture of this catfish in captivity including for the breeding, nursery, stocking and growout, including advice on pre- and post-stocking practices, harvesting and health management.