Salinity is a growing global challenge, affecting soil productivity, freshwater availability, and aquatic ecosystems. Inland saline aquaculture presents a sustainable opportunity to utilise salt-affected water resources for food production. This article examines the prospects and challenges of aquaculture in inland saline environments, focusing on soil and water characteristics, species tolerance, and mitigation strategies. It highlights the potential of using brackish groundwater for aquaculture, reducing pressure on freshwater supplies while making use of degraded lands. The study also discusses the physiological adaptations of fish to salinity stress, the role of key ions in aquaculture success, and the integration of saline aquaculture with traditional farming systems. Inland saline aquaculture could play a critical role in enhancing food security, optimising water resource use, and mitigating environmental degradation in semi-arid and arid regions.