Mariska Bottema (WorldFish) and Rebecca McMillan (IDRC) discuss the concept of nature-based aquaculture, why it matters for innovation and entrepreneurship, and how it can support ecosystems, communities, and profitability. Topics include: Defining nature-based aquaculture and its connection to nature-based solutions; criteria such as climate resilience, ecosystem health, reduced antimicrobial use, and inclusivity; global examples: mangrove–shrimp integration, women-led seaweed farming, integrated multi-trophic systems, and rice–fish farming; supportive technologies including IoT, renewable energy, and life cycle assessment; and opportunities for entrepreneurs: resilient farms, reduced risks, lower costs, premium markets, funding, and partnerships.