Feed is an important input that involves nearly 60% of the total production cost in commercial aquaculture. Hence, nutritionally balanced and cost-effective diets play a large role in deciding the return from an aquaculture venture. Nutritionists are searching for alternative ingredients and approaches to offset the use of fishmeal in aquaculture feeds. This article discusses strategies to reduce feed cost by promoting gut health and nutrient utlilisation, including: Use of probiotics and prebiotics, supplementation with exogenous enzymes, essential nutrients and chemoattractants, and use of other feed additives such as acidifiers to improve digestibility and mycotoxin binders.